Safety
PAN has been employed in an identical manner for millions of administrations in routine dental practice, for over 50 years without a single serious side effect ever having been reported.

Avoids Animal Experiments
The safety, fine control and evanescent effects available when using PAN enable the investigator to work directly in humans without using experimental animals. Apart from the undesirability of using animals for experimentation from a humanitarian viewpoint, there are practical snags associated with such work. Among these, are the problems associated with extrapolating observations from one species to another. For instance, animal experiments examining the side effects of thalidomide gave no indication of its potential to cause human birth defects.