SABRI

 

The South African Brain Research Institute

Annual Report for 2010 - 2011

 

 

ãLeading substance abuse authority looking at the possibility of researching PAN in UK

 

ãChinese interest in nicotine addiction treatment 

 

ãAnglo-American’s Chairman’s Fund sees the potential of SABRI’s PAN treatment and again provide funding   



South African Brain Research Institute

Incorporated association not for gain

Reg No 1982/000063/08

PBO No 18/11/13/2888 

Fund Raising No 001-356 NPO

6 Campbell St

Waverley

Johannesburg 2090

Gauteng, South Africa

P O Box 1315

Highlands North 2037

Johannesburg

South Africa

Telephone (011) 786-2912

Fax (011) 786-1766 E-mail: mag@sabri.org..za

Website  www.sabri.org.za

BENEFICIARY OF: NATIONAL LOTTERY DISTRIBUTION TRUST

 


On the positive side and after a number of years, our founding sponsor, Anglo-American Chairman’s Fund has again come on board to assist with SABRI’s funding. They believe that SABRI’s Capacity Building Project has the potential to make a major contribution to South African healthcare in both the private and public sectors.

SABRI struggles to introduce the psychotropic analgesic nitrous oxide (PAN) therapy into the public hospital sector in South Africa. Clearly, this is the major task, but ignorance and preconceptions still dog the pathway to the goal. The main problem seems to be the parlous state of the state health services. There does not seem to be any real leadership and morale is extremely low at many governmental hospitals. The welfare of patients’ is no longer the chief concern. The recent public health workers strike is a case in point. The low priority placed on service to patients was seen in countless places, which in some cases led to fatalities. A typical example is that of an anaesthetist, whose life was threatened on his way to a strike-bound hospital. As a result, he resigned from the public health sector. What makes this even more distressing is that he was very keen on getting the PAN therapy more widely used in the public sector. He was so interested that he went out of his way to attend a course on PAN given by SABRI’s CEO. Such farsighted medical professionals are few and far between. Our experience to date is that the actual introduction of PAN into a public health facility is only the first stage in what often appears to be an obstacle course. Often, without strong leadership, the equipment lies idle because the doctors have such low morale that they don’t care whether something that has been proven to assist patients is used or not. The morale of nursing staff is also a major problem. Without their strong commitment they often block the use of a new therapy.  

One of the most disheartening aspects is that the lack of foresight and obstruction has usually originated from the determined mindless opposition of medically qualified personnel who are unable to grasp the fact that a home-grown South African medical discovery has any value. Of course, there have been a number of exceptions, but these are few in number indeed. One of these exceptions is Dr Emeka Ezenwugo, who until recently was the medical superintendent of Letaba Hospital in in Limpopo. Although he had to fight opposition from both medical and administrative staff of his hospital, he engaged the CEO of SABRI to introduce the therapy to his hospital. Dr Ezenwugo could visualise the benefit of the PAN, but also understands (through personal experience) the difficulties of moving the PAN forward into the public sector.

Another example comes from the private sector viz., Dr Brian Brink Group Medical Consultant at Anglo-American, who believes that the use of PAN could be one of the most important primary health initiatives not only for S.A., but for Africa and the world. To give the reader an idea of Dr Brink’s expertise in the health care sector and prescient achievements to date; he was the doctor who years ago realised that the mining industry in S.A. must treat all their employees for HIV-AIDS. Most of his seminal work on the project was conducted while the ruling party was led by an “Aids” – denialist. It is now well-known that largely due to his visionary work and influence, that treating their workers with anti-retrovirals is now the norm in the mining industry. Clearly, once the mining industry had shown the way, the public health authorities had to follow suit, without being able to fall back on the excuse that there was no large-scale model available showing that it could be done. Indeed, it is possible that the way forward for SABRI to get the PAN used in the public sector is to get a massive buy-in from the private sector, which would lead the way for the public sector.

Apart from PAN’s use in rural settings, many thousands of people have benefited from the PAN therapy, in South Africa,  Europe and North America. Our scientific success and the practical benefits of the treatment are a tribute to all our distinguished sponsors, to whom we are extremely grateful. A list of these follows at the end of the annual report.

 

SOUTH AFRICAN PROGRESS

 

Professor Gillman continues to train undergraduate and postgraduate health professionals at the University of Limpopo’s Medunsa Campus. He usually spends a full week every year doing so. The university has recently purchased two further PAN machines, which will enable undergraduate students to obtain practical experience of the technique.  As mentioned above, there was also a training for doctors and dentists at Letaba Hospital in Limpopo. 

PAN for treating nicotine addiction funded by the South African Dental Association (SADA), the South African Medical Association (SAMA) and Afrox was published on 7 December 2010, by Cerebrum Publishers.

As has been the case for the last few years and since it is the main thrust of SABRI’s outreach project, a short outline of SABRI’s Capacity Building project follows.   

 

Psychotropic Analgesic Nitrous oxide (PAN) for Hospital & Primary Health Care Centres for Minor Surgery and Acute Addictive Withdrawal States

 

Substance abuse is a chronic, devastating and debilitating disease, with serious social, psychological, economic and physical implications for the individual and the community. For instance, HIV-AIDS transmission is increased by the risk- taking behaviour associated with substance abuse and the progression of the disease is also increased because substance abuse compromises the immune system and decreases compliance with anti-retroviral medications.  

The problem of substance abuse is greater than ever before, hence the need for more effective treatments.   

 

 

 

 

The Project

 

1)         Health professionals from organisations will be trained to administer PAN to enhance and complement treatment that they provide to substance abusers, hence facilitating recovery. Recovery is positive for the individual and society, including the prevention of HIV transmission and increasing the survival of those already infected.

 

2)         All who are trained will also be able to administer PAN in the identical manner at the same healthcare centre to relax patients and control pain during minor surgery, avoiding costly hospital admissions and general anaesthetics. 

 

What is PAN?

PAN is the use of nitrous oxide (laughing gas) and oxygen to successfully treat addiction. This treatment is unique in S.A. Medical History being the first therapy officially recognised by the medical authorities, which had been wholly conceptualised, researched and developed in S.A. without overseas input.  SABRI has published over 150 scientific contributions on the PAN therapy in prestigious journals including BMJ, Lancet and American Journal of Medicine. Many thousands of patients both nationally and internationally have benefited.  

Although counselling, support groups and other interventions are extremely important, these alone are often insufficient to break the physical and psychological dependence on drugs such as alcohol, cannabis (dagga), benzodiazepines (Valium, Librium, etc.), cocaine, heroin, methaqualone (Mandrax) and nicotine.

Withdrawal symptoms and craving following abstinence from these drugs weakens the will of even the strongest person trying to ‘kick’ the habit, making them very susceptible to relapse. On average, 90% of substance abusers relapse and begin reusing within days or months of being detoxified (i.e. removal of offending drug from the patient’s system); largely due to craving. These repeated detoxifications put great pressure on our already overcrowded hospitals.

The PAN treatment offers a medically proven, cost-effective and safe tool for breaking the cycle of addiction. Those treated with PAN can continue being economically and socially active. The care-givers, who often themselves are discouraged by relapses, and the community, will have a powerful, readily available and accessible means of combating substance abuse and relapse prevention. PAN has an unrivalled safety record and can be used over the short period needed without harm.

A trained nurse using PAN can treat patients inexpensively as outpatients, without direct physician supervision, avoiding costly hospital admissions. Apart from substance abuse, she/he can also undertake minor surgical procedures. Hospital bed-occupations, average R1255 per day and withdrawal treatments require at least 3 days.  The PAN therapy avoids at least 90% of inpatient detoxification therapies, as shown wherever it has been introduced. Together with the savings if PAN is also substituted for general anaesthetics for minor surgery, a small investment i.e. R150 000, for each site, will result in savings of 2.15 million Rand per site/per annum in unnecessary bed occupations and medical personnel costs for surgery and detoxifications.  

The necessary equipment is commercially available and can be installed within days of payment.  A new site can be fully operational within 6 weeks of equipment installation. 

 

SABRI'S INTERNATIONAL COLLABORATIONS

 

One of the other highlight of SABRI’s activities this year was the publication of the CEO’s book Treating Nicotine Dependence with Nitrous Oxide/Oxygen (PAN). As a courtesy, a copy of the book was sent to Professor Morris Clark of the University of Colorado at Denver, who kindly wrote the Foreword. He is also the author of the standard text on PAN. After receiving a copy of the book, he showed it to some Chinese visitors, who were very taken with it and indicated their interest in using the technique in China. Smoking is a major problem in China. As can be imagined, a breakthrough in China would bring the PAN therapy to millions if not billions of people. And possibly, if it were used there it might wake our local health authorities to the usefulness of a treatment that has been so spurned in S.A. 

Professor David Nutt, who until recently was the scientific advisor to the British Government on substance abuse, has also expressed interest in researching PAN.      

 

ACKNOWLEDGEMENTS

 

SABRI acknowledges with thanks, all those who have helped to ensure another successful year for SABRI. We are sad to say that Mr Simon Maduna has had to leave the Board of SABRI for reasons of ill-heath. Ms Bridgett Schultz has kindly agreed to take his place. We would also like to express our deepest gratitude to Mr E Maduna for his fine work over the year under review. Last but certainly not least, we wish to thank our distinguished donors for their continued support.

 

Professor Mark A Gillman

Chief Executive Officer


LIST OF SPONSORS SUPPORTING SOUTH AFRICAN BRAIN

RESEARCH INSTITUTE AS AT 31 MARCH 2009


 

1.     Anglo American and De Beers Chairman's Fund

2.     First National Bank of SA Ltd

3.     JCI Ltd

4.     Standard Bank Group Ltd

5.     Allied Building Society

6.     Afrox Ltd

7.     Sage Holdings Ltd

8.     Barlow Rand Ltd

9.     Liberty Life Group Community Fund

10.   Watters Stationery (Pty) Ltd

11.   Booth Bequest

12.   Anglovaal Ltd

13.   Times Media Ltd

14.   MSD (Pty) Ltd

15.   Lifegro Assurance Ltd

16.   The Premier Group Charitable

       Community Trust

17.   Suncrush Ltd

18.   Everite Ltd

19.   Blue Circle Ltd

20.   Elcentre Corporation Ltd

21.   IGI Ltd

22.   Rank Xerox Ltd

23.   Clicks Stores

24.   Wilson-Rowntree (Pty) Ltd

25.   Investec Bank Ltd

26.   Wooltru Ltd

27.   Nashua Vaal Ltd

28.   Algorax Ltd

29.   Max Paiken Printers

30.   Magnum Airlines Ltd

31.   Federale Volksbeleggings Ltd

32.   Ingersoll-Rand Co SA (Pty) Ltd

33.   E.R. Bernard & Associates

34.   The Robert Niven Trust

35.   Romens Holdings Ltd

36.   Aroma Liquor Holdings Ltd

37.   AECI Ltd

38.   M & S Spitz Footwear Holdings Ltd

39.   The Foschini Group Ltd

40.   Samancor Ltd

41.   Industrial Development

       Corporation of SA

42.   S.A. Medical Research Council

43.   PFV Group Management Services

       (Pty) Ltd

44.   Mathieson & Ashley Holdings Ltd

45.   The Lion Matches Co. Ltd

46.   Langerberg Foods Ltd

47.   Pick & Pay Stores Ltd

48.   National Beverage

       Service (Pty) Ltd

49.   National Discount House

        of SA Ltd

50.   Wyeth-Ayerst (Pty) Ltd

51.   The Spar Guild of SA

52.   Associated Diesel Co. (Pty) Ltd

53.   The Good Year Tyre

       & Rubber Co

54.   The Mannie Auctioneering

55.   Malbak Ltd

56.   JHI Ltd

57.   Eskel Jawitz

58.   Total SA

59.   Datacraft

60.   Nicholas Yale cc

61.   Mercantile & General
Reinsurance Co. of SA

62.   Late Mr M Pelkowitz

63.   J D Group Ltd

64.   Access Security

65.   Carlton Paper of SA

66.   Upjohn (Pty) Ltd

67.   D P I Plastic (Pty) Ltd

68.   Momentum Life Assurers Ltd

69.   S M Paiker

70.   Union Mosaic Tiles (Pty) Ltd

71.   Truworths

72.   Metro Group Ltd

73.   Walter A Chipkin (Pty) Ltd

74.   Saficon Investment Ltd

75.   Afrolympic Travels (Pty) Ltd

76.   Medsed

77.   Market Toyota

78.   Nashua Ltd

79.   Rio Tinto Management Services

80.   Vinuchi (Pty) Ltd

81.   Sandra Michele Lampert

82.   Mobil SA Energy Co Ltd

83.   Ellies Electronics

84.   Sentrachem Ltd

85.   Fred C Smollan (Pty) Ltd