SABRI

 

The South African Brain Research Institute

Annual Report for 2009 - 2010

 

 

ãSABRI’s PAN therapy to be introduced to Australia and described as a major breakthrough for treating substance abuse by Australians

 

ãSABRI’s CEO commissioned to write book on nitrous oxide and neurotransmitters by USA publisher 

 

ãSABRI’s CEO appointed as editorial adviser to another international medical journal  

 



South African Brain Research Institute

Incorporated association not for gain

Reg No 1982/000063/08

PBO No 18/11/13/2888 

Fund Raising No 001-356 NPO

6 Campbell St

Waverley

Johannesburg 2090

Gauteng, South Africa

P O Box 1315

Highlands North 2037

Johannesburg

South Africa

Telephone (011) 786-2912

Fax (011) 786-1766 E-mail: mag@sabri.org..za

Website  www.sabri.org.za

BENEFICIARY OF: NATIONAL LOTTERY DISTRIBUTION TRUST

 


The important task of introducing the psychotropic analgesic nitrous oxide (PAN) therapy into the public hospital sector in South Africa remains the main thrust of SABRI’s endeavours.  Introduction of the therapy into the public sector has been a major ambition of SABRI almost since it’s foundation in 1982. The first important milestone along this journey was the recognition by the Director General of the Department of Health and Social Services in Mpumalanga, Dr C Moloko. He had the foresight to acknowledge SABRI’s breakthrough in discovering the use of PAN for treating substance abuse as well as its previously proven usefulness for minor surgery. He also realised the practical importance of applying it in the public sector. When the decision was taken to introduce PAN into public hospitals nobody at SABRI had the vaguest idea of what lay ahead.  Nobody could have foreseen the number of obstacles that would be rolled out by government bureaucracy to obfuscate and retard progressing this innovation.  The sad thing is that by slowing the progress into the public sector, these incompetents are preventing those in most need, i.e. the underprivileged and previously disadvantaged from benefiting from this safe and cost-effective medical intervention.  The fact that we have progressed as far as we have, is a great tribute to SABRI’s perseverance; after years of chipping away at the resistance offered by wooden, unimaginative governmental officials and their equally stilted medical personnel.  This obstructive behaviour and lack of willingness to go beyond the banal has made SABRI’s task fraught. The most difficult aspect to accept is that the lack of foresight and obstruction has usually originated from the stern mindless opposition of medically qualified personnel who are unable to grasp the fact that a home-grown South African medical discovery has any value. Of course, there have been a number of exceptions, but these are few in number indeed.  However, at last, despite the limitations alluded to, there is progress. 

 

In spite of its important work for South African public health, education and advances into the public sector, SABRI is still chronically short of funding. Notwithstanding, SABRI’s continues to contribute to international brain research.

 

The introduction of the PAN into the public sector clearly has major social and economic benefits for South Africa and indeed Africa. As the number of hospitals using the approach increases, the savings to the governmental medical services will rise exponentially (see below). With no commercial sponsorship and opposition from vested interests, raising donations for SABRI’s work has become increasingly difficult. The fact that PAN is ideally suited for use, not only in hospitals but also primary health care facilities, is still not extensively recognised by potential donors.  A fact that is most surprising since we are a Third World country that recognises the need for ‘low-tech’ economical methods. The PAN technique is indeed ‘low-tech’ and has a successful track history of over 25 years in primary health care facilities in rural and urban localities.  An excellent example is that PAN was used successfully and safely by trained nursing sisters for over 15 years in Dirkiesdorp.  The latter is a tiny village between Piet Retief and Wakkerstroom.  Although the gases were administered by nurses, the nearest supervising physician, who visited the site once per month only, was situated in Newcastle 90 kilometres distant.  Apart from PAN’s use in rural settings, many thousands of people have benefited from the PAN therapy, in South Africa,  Europe and North America. Despite our continuing difficulty in raising funds, we are grateful for the support received from our existing and past donors, listed at the end of the annual report.   

 

SOUTH AFRICAN PROGRESS

 

On the local front, the CEO of SABRI, continues to train health professionals at the University of Limpopo’s Medunsa Campus, although he only spends a few weeks teaching there every year.

 

The work in Mpumalanga has progressed further. Indeed, a training course will be conducted at the Rob Ferreira Hospital, to train health personnel, which is the main public hospital in the province.  Rob Ferreira has purchased two new PAN machines and these will be installed soon. 

 

During the year numerous CPD (Continuing Professional Development) courses and lectures on PAN were given by the CEO.  This included one each for the staff at Kalafong Hospital in Tshwane and to primary health care professionals of the Gauteng Department of Health at the Carel Kruger Building in Pretoria

 

The instructional book on using PAN for treating nicotine addiction funded by the South African Dental Association (SADA) and the South African Medical Association (SAMA) will be published shortly. Now perhaps, it might be worthwhile to give readers a brief outline of the project that has formed the major thrust of SABRI over the last years.

 

Psychotropic Analgesic Nitrous oxide (PAN) for Hospital & Primary Health Care Centres for Minor Surgery and Acute Addictive Withdrawal States

 

Substance abuse is a chronic, devastating and debilitating disease, with serious social, psychological, economic and physical implications for the individual and the community. For instance, HIV-AIDS transmission is increased by the risk- taking behaviour associated with substance abuse and the progression of the disease is also increased because substance abuse compromises the immune system and decreases compliance with anti-retroviral medications.  

The problem of substance abuse is greater than ever before, hence the need for more effective treatments.   

 

The Project

 

1)         Health professionals from organisations will be trained to administer PAN to enhance and complement treatment that they provide to substance abusers, hence facilitating recovery. Recovery is positive for the individual and society, including the prevention of HIV transmission and increasing the survival of those already infected.

 

2)         All who are trained will also be able to administer PAN in the identical manner at the same healthcare centre to relax patients and control pain during minor surgery, avoiding costly hospital admissions and general anaesthetics. 

 

What is PAN?

 

PAN is the use of nitrous oxide (laughing gas) and oxygen to successfully treat addiction. This treatment is unique in S.A. Medical History being the first therapy officially recognised by the medical authorities, which had been wholly conceptualised, researched and developed in S.A. without overseas input.  SABRI has published over 150 scientific contributions on the PAN therapy in prestigious journals including BMJ, Lancet and American Journal of Medicine. Many thousands of patients both nationally and internationally have benefited.  

 

Although counselling, support groups and other interventions are extremely important, these alone are often insufficient to break the physical and psychological dependence on drugs such as alcohol, cannabis (dagga), benzodiazepines (Valium, Librium, etc.), cocaine, heroin, methaqualone (Mandrax) and nicotine.

 

Withdrawal symptoms and craving following abstinence from these drugs weakens the will of even the strongest person trying to ‘kick’ the habit, making them very susceptible to relapse. On average, 90% of substance abusers relapse and begin reusing within days or months of being detoxified (i.e. removal of offending drug from the patient’s system); largely due to craving. These repeated detoxifications put great pressure on our already overcrowded hospitals.

 

The PAN treatment offers a medically proven, cost-effective and safe tool for breaking the cycle of addiction. Those treated with PAN can continue being economically and socially active. The care-givers, who often themselves are discouraged by relapses, and the community, will have a powerful, readily available and accessible means of combating substance abuse and relapse prevention. PAN has an unrivalled safety record and can be used over the short period needed without harm.

 

A nursing sister using PAN can treat patients inexpensively as outpatients, without direct physician supervision, avoiding costly hospital admissions. Hospital bed-occupations, average R1255 per day and withdrawal treatments require at least 3 days.  The PAN therapy avoids at least 90% of inpatient detoxification therapies, as shown wherever it has been introduced. Together with the savings if PAN is also substituted for general anaesthetics for minor surgery, a small investment i.e. R143 000, for each site, will result in savings of 2.15 million Rand per site/per annum in unnecessary bed occupations and medical personnel costs for surgery and detoxifications.  

 

The necessary equipment is commercially available and can be installed within days of payment.  A new site can be fully operational within 6 weeks of equipment installation. 

 

SABRI'S INTERNATIONAL COLLABORATIONS

 

The highlight of SABRI’s activities this year was the visit of two distinguished Australian visitors. Dr J Gelb, expert on ‘crisis psychiatry’ and respected consumerist Mr P Darroch. Dr Gelb has conducted a weekly Mental Health segment on radio in Australia and has a special interest in substance abuse. Mr Darroch is on the prestigious Cochrane Collaboration Consumer Network related to substance abuse and has an interest in scientific misconduct. They visited three Eastern Province clinics to assess the PAN substance abuse therapy. Both stated that the use of PAN was a major breakthrough in the treatment of substance abuse and will introduce the PAN therapy to Australia in the near future.

 

SABRI’s CEO has been commissioned by a U.S.A publisher to write the book titled ‘Neurotransmitters involved in the actions of nitrous oxide’ and was appointed to the editorial board of another international scientific journal (Aging Health).

 

ACKNOWLEDGEMENTS

 

SABRI acknowledges with the thanks, the many unnamed individuals who have contributed to SABRI’s continued success.  . Mr Eddie Maduna Chief of Administration of SABRI has worked with his usual quite efficiency and deserves much thanks.   The generous support of our sponsors is gratefully acknowledged. We thank them all!

 

Professor Mark A Gillman

Chief Executive Officer


LIST OF SPONSORS SUPPORTING SOUTH AFRICAN BRAIN

RESEARCH INSTITUTE AS AT 31 MARCH 2009


 

1.     Anglo American and De Beers Chairman's Fund

2.     First National Bank of SA Ltd

3.     JCI Ltd

4.     Standard Bank Group Ltd

5.     Allied Building Society

6.     Afrox Ltd

7.     Sage Holdings Ltd

8.     Barlow Rand Ltd

9.     Liberty Life Group Community Fund

10.   Watters Stationery (Pty) Ltd

11.   Booth Bequest

12.   Anglovaal Ltd

13.   Times Media Ltd

14.   MSD (Pty) Ltd

15.   Lifegro Assurance Ltd

16.   The Premier Group Charitable

       Community Trust

17.   Suncrush Ltd

18.   Everite Ltd

19.   Blue Circle Ltd

20.   Elcentre Corporation Ltd

21.   IGI Ltd

22.   Rank Xerox Ltd

23.   Clicks Stores

24.   Wilson-Rowntree (Pty) Ltd

25.   Investec Bank Ltd

26.   Wooltru Ltd

27.   Nashua Vaal Ltd

28.   Algorax Ltd

29.   Max Paiken Printers

30.   Magnum Airlines Ltd

31.   Federale Volksbeleggings Ltd

32.   Ingersoll-Rand Co SA (Pty) Ltd

33.   E.R. Bernard & Associates

34.   The Robert Niven Trust

35.   Romens Holdings Ltd

36.   Aroma Liquor Holdings Ltd

37.   AECI Ltd

38.   M & S Spitz Footwear Holdings Ltd

39.   The Foschini Group Ltd

40.   Samancor Ltd

41.   Industrial Development

       Corporation of SA

42.   S.A. Medical Research Council

43.   PFV Group Management Services

       (Pty) Ltd

44.   Mathieson & Ashley Holdings Ltd

45.   The Lion Matches Co. Ltd

46.   Langerberg Foods Ltd

47.   Pick & Pay Stores Ltd

48.   National Beverage

       Service (Pty) Ltd

49.   National Discount House

        of SA Ltd

50.   Wyeth-Ayerst (Pty) Ltd

51.   The Spar Guild of SA

52.   Associated Diesel Co. (Pty) Ltd

53.   The Good Year Tyre

       & Rubber Co

54.   The Mannie Auctioneering

55.   Malbak Ltd

56.   JHI Ltd

57.   Eskel Jawitz

58.   Total SA

59.   Datacraft

60.   Nicholas Yale cc

61.   Mercantile & General
Reinsurance Co. of SA

62.   Late Mr M Pelkowitz

63.   J D Group Ltd

64.   Access Security

65.   Carlton Paper of SA

66.   Upjohn (Pty) Ltd

67.   D P I Plastic (Pty) Ltd

68.   Momentum Life Assurers Ltd

69.   S M Paiker

70.   Union Mosaic Tiles (Pty) Ltd

71.   Truworths

72.   Metro Group Ltd

73.   Walter A Chipkin (Pty) Ltd

74.   Saficon Investment Ltd

75.   Afrolympic Travels (Pty) Ltd

76.   Medsed

77.   Market Toyota

78.   Nashua Ltd

79.   Rio Tinto Management Services

80.   Vinuchi (Pty) Ltd

81.   Sandra Michele Lampert

82.   Mobil SA Energy Co Ltd

83.   Ellies Electronics

84.   Sentrachem Ltd

85.   Fred C Smollan (Pty) Ltd

86.   Calvert Removals (Pty) Ltd

87.   ATC (Pty) Ltd

88.   Perm

89.   Sanlam

90.   Caltex Oil (SA) (Pty) Ltd

91.   Bankorp Ltd

92.   Greenfield Manufacturing Co (Pty) Ltd

93.   Johnson Matthey (Pty) Ltd

94.   OK Bazaars Ltd

95.   Fedlife Assurance Ltd

96.   Top Life

97.   L. Suzman Distributors (Pty) Ltd

98.   NBS Holdings Ltd

99.   Norwich Life SA Ltd

100. Unitrans Ltd

101. Bushfeld Flowers

102. Emmanuels Personnel

103. Safmarine

104. SA Press Cutting Agency

105. T & N Holdings Ltd

106. The Bidvest Group Ltd

107. Group Five Ltd

108. The R B  Hagart Trust

109. Nedcor Ltd

110. Kempston Truck Hire Ltd

111. Foundation for Research Development

112. Lundbeck South Africa (Pty) Ltd

113. Scaw Metals Ltd

114. Trident Steel (Pty) Ltd

115. Sappi Ltd

116. African Life Assurance Co Ltd

117. (Metboard) The Stella & Paul Loewenstein Trust

118. Rheem South Africa

119. Guardian National Insurance Co Ltd

120. African Sales Co (Pty) Ltd

121. Irvin & Johnson Ltd

122. Werkmans Attorneys

123. JH Isaacs Group Ltd

124. The Hans Merensky Foundation

125. Anglo-Alpha Ltd

126. Slavepak Holdings (Pty) Ltd

127. SAB

128. Malcolm & Gladys Cameron Foundation

129.   M.I.B. Group (Pty) Ltd

130.   Boardman Bros (Pty) Ltd

131.   Da Gama Textile Ltd

132.   Sandoz Products (Pty) Ltd

133.   Pfizer Products (Pty) Ltd

134.   Eli Lilly (SA) (Pty) Ltd

135.   Nestle (SA) (Pty) Ltd

136.   Decor Group

137.   Ernest Joseph & Co (Pty) Ltd

138.   Barbizon Tea and Coffee Ltd

139.   Gencor Develpoment Trust

140.   UU Net Internet Africa

141.   The PG Foundation

142.   IBM South Africa

143.   Chemical Services Ltd

144.   The Wartenweiler Trust

145.   Engen Petroleum Limited

146.   The E Bellairs Charitable Trust

147.   Rhone-Poulenc Rorer S.A. (Pty) Ltd

148.   SmithKline Beecham Pharmaceutical (Pty) Ltd.

149.   The Carl & Emily Fuchs Foundation

150.   Rex Trueform Clothing Co  Ltd

151.   Compu-Clearing (Pty) Ltd

152.   Peregrine Structuring  (Pty)    Ltd

153.   Billiton Development Trust

154.   Metropolis Transactive (Pty) Ltd

155.   Sasol S.A. Ltd

156.   Gold Reef City Casino

157.   Bequest Late Mr LA Marks

158.   Data Pro

159.   Edward L. Bateman Ltd

160.   Caxton Publishers & Printers

161.   National Lottery Distribution Trust Fund

162.   Hosken Consolidated Investments Foundation

163.   Rainbow Farms (Pty) Limited

164.   Ellerine Holdings Limited

165.   Dentsply SA

166.   Transnet Foundation

167.   BOE